Pengaruh Kecerdasan Emosional dan Kemandirian Belajar terhadap Prestasi Belajar Mata Pelajaran Ekonomi Siswa Kelas XII SMA Negeri 33 Jakarta

This study aims to determine the significant effect of emotional intelligence and learning independence on learning achievement in economics subjects. This study used 60 samples from class XII SMA Negeri 33 Jakarta, using a quantitative approach with quantitative research methods through questionnaire research instruments, library research and field research such as surveys, interviews, direct observations in schools. The results of the analysis prerequisite test show that all variables meet the requirements, and based on the results of this study it can be concluded that there is a significant influence of emotional intelligence on learning achievement with the acquisition of Sig. 0.000 <0.05 contribution of 21.27% and there is a significant effect of learning independence on learning achievement with the acquisition of Sig. 0.000 < 0.05 contribution of 49.9%. In this study, there is a correlation between variables and simultaneously emotional intelligence and learning independence affect student learning achievement. Researchers suggest that students are better able to get used to being independent in learning, independent in the sense of being able to find various sources of information or knowledge from several sources of knowledge not only from one economics teacher at school

ELM : A Low-Latency and Scalable Memory Encryption Scheme

Memory encryption with an authentication tree has received significant attentions due to the increasing threats of active attacks and the widespread use of non-volatile memories. It is also gradually deployed to real-world systems, as shown by SGX available in Intel processors. The topic of memory encryption has been recently extensively studied, most actively from the viewpoint of system architecture. In this paper, we study the topic from the viewpoint of provable secure symmetric-key designs, with a primal focus on latency which is an important criterion for memory. A progress in such a direction can be observed in the memory encryption scheme inside SGX (SGX integrity tree or SIT). It uses dedicated, low-latency symmetric-key components, i.e., a message authentication code (MAC) and an authenticated encryption (AE) scheme based on AES-GCM. SIT has an excellent latency, however, it has a scalability issue for its on-chip memory size. By carefully examining the required behavior of MAC and AE schemes and their interactions in the tree operations, we develop a new memory encryption scheme called ELM. It consists of fully-parallelizable, low-latency MAC and AE schemes and utilizes an incremental property of the MAC. Our AE scheme is similar to OCB, however it improves OCB in terms of decryption latency. To showcase the effectiveness, we consider instantiations of ELM using the same cryptographic cores as SIT, and show that ELM has significantly lower latency than SIT for large memories. We also conducted preliminary hardware implementations to show that the total implementation size is comparable to SIT

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.

BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (DSBs), mediators including ATM are recruited to the site of DNA-damage. Subsequent phosphorylation of p53 by ATM and ATM-induced CHK2 results in p53 stabilization, ultimately intensifying transcription of p53-responsive genes involved in DNA repair, cell-cycle checkpoint control and apoptosis. METHODS: In the current study, we investigated the stabilization and activation of p53 and associated DDR proteins in response to treatment of human colorectal cancer cells (HCT116p53+/+) with the MDM2 antagonist, Nutlin-3. RESULTS: Using immunoblotting, Nutlin-3 was observed to stabilize p53, and activate p53 target proteins. Unexpectedly, Nutlin-3 also mediated phosphorylation of p53 at key DNA-damage-specific serine residues (Ser15, 20 and 37). Furthermore, Nutlin-3 induced activation of CHK2 and ATM - proteins required for DNA-damage-dependent phosphorylation and activation of p53, and the phosphorylation of BRCA1 and H2AX - proteins known to be activated specifically in response to DNA damage. Indeed, using immunofluorescent labeling, Nutlin-3 was seen to induce formation of γH2AX foci, an early hallmark of the DDR. Moreover, Nutlin-3 induced phosphorylation of key DDR proteins, initiated cell cycle arrest and led to formation of γH2AX foci in cells lacking p53, whilst γH2AX foci were also noted in MDM2-deficient cells. CONCLUSION: To our knowledge, this is the first solid evidence showing a secondary role for Nutlin-3 as a DDR triggering agent, independent of p53 status, and unrelated to its role as an MDM2 antagonist

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

SARS-CoV-2オミクロンBA.2.75株（通称ケンタウロス）のウイルス学的性状の解明. 京都大学プレスリリース. 2022-10-12.The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions